Topoisomerase II is a structural component of mitotic chromosome scaffolds.
We’ve got obtained a polyclonal antibody that acknowledges a serious polypeptide element of hen mitotic chromosome scaffolds. This polypeptide migrates in SDS PAGE with Mr 170,000. Oblique immunofluorescence and subcellular fractionation experiments affirm that it’s current in each mitotic chromosomes and interphase nuclei. Two strains of proof counsel that this protein is DNA topoisomerase II, an plentiful nuclear enzyme that
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