Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin alpha v beta 3 potentiate bone resorption.

We now have investigated the mechanism by which osteoclasts adhere to and resorb bone. We present that these cells categorical beta 1 and beta Three integrins that are concerned in attachment to purified bone matrix proteins. Binding to osteopontin and bone sialoprotein is mediated by alpha v beta 3, whereas a beta 1 integrin is

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